Bone Abstracts

see PP293....

Wnt/β-catenin signaling, also called canonical Wnt signaling, is important for regulating bone formation. Previous studies reported that deletion of secreted frizzled-related protein (sFRP1), a Wnt antagonist, enhanced trabecular bone accrual in adult mice. Tadalafil, an inhibitor of phosphodiesterase 5 (PDE5), is widely used for treating male erectile dysfunction (ED) in clinical. Inhibition of PDE5 increases cGMP levels and then activates cGMP-dependent protein kinase (...

see PP70....

Members of the Rho family including small GTPase Cdc42 have been shown to play multiple roles in cell regulation, including regulation of cytoskeletal organization, cell migration, proliferation, and apoptosis. However, their tissue-specific roles in vivo, especially in limb bud mesenchyme, remain largely unknown. Herein, we report that conditional deletion of Cdc42 in AER dose not change the limb development, however, knockout of Cdc42 in mesenchymal stem cells of li...